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Rebecca L. Pfeiffer, PhD

  • Assistant Professor of Ophthalmology

Dr. Pfeiffer’s graduate studies focused on parallels between brain diseases and eye diseases, and her current research explores how the retina rebuilds after injury or disease-related degeneration. She was first introduced to research as a potential career path through a job in a neuroscience lab that she had as an undergraduate student. Dr. Pfeiffer had originally planned to go into clinical medicine, but through this job at the lab, decided to pursue research instead.

As a graduate student, she began looking at metabolism changes in diseased Mueller cells, which are unique cells found only in the retina.

As a Postdoctoral Research Associate, Dr. Pfeiffer developed a focus on the relationships between neurons and glia within the retina. This is a unique area to study. Additionally, Dr. Pfeiffer is studying how glia interact with synapses within the nervous system. She is looking to find out if communication between synapses follows consistent patterns in both healthy eyes and eyes with diseases.

In the future, Dr. Pfeiffer hopes to study how transporters interact with neurons and glia and how glia impact disease. She may use immune-electrode microscopy and super resolution microscopy to examine these topics.

Division

    Education & Training

  • 2017-2023 Postdoctoral Research: Moran Eye Center, University of Utah, PI: Bryan Jones
  • 2017 PhD in Neuroscience: University of Utah, Salt Lake City UT, Advisor: Robert Marc; Dissertation title: Persistent Remodeling and Neurodegeneration in Late-Stage Retinal Degeneration
  • 2010 BS in Biology (summa cum laude), University of New Mexico, Albuquerque, NM
Representative Publications

Sigulinsky CL, Pfeiffer RL, Jones BW. Retinal Connectomics: A Review. Annu Rev Vis Sci. 2024 Sep;10(1):263-291. doi: 10.1146/annurev-vision-102122-110414. Review. PubMed PMID: 39292552

Pfeiffer RL, Anderson JR, Dahal J, Garcia JC, Yang JH, Sigulinsky CL, Rapp K, Emrich DP, Watt CB, Johnstun HA, Houser AR, Marc RE, Jones BW. A pathoconnectome of early neurodegeneration: Network changes in retinal degeneration. Exp Eye Res. 2020 Oct;199:108196. doi: 10.1016/j.exer.2020.108196. Epub 2020 Aug 15. PubMed PMID: 32810483; PubMed Central PMCID: PMC7554222

Farzad S, Kosta P, Iseri E, Walston ST, Bouteiller JC, Pfeiffer RL, Sigulinsky CL, Yang JH, Garcia JC, Anderson JR, Jones BW, Lazzi G. Impact of Retinal Degeneration on Response of ON and OFF Cone Bipolar Cells to Electrical Stimulation. IEEE Trans Neural Syst Rehabil Eng. 2023;31:2424-2437. doi: 10.1109/TNSRE.2023.3276431. Epub 2023 May 26. PubMed PMID: 37186528; PubMed Central PMCID: PMC10324560

Pfeiffer RL, Jones BW. Retinal Pathoconnectomics: A Window into Neurodegeneration. Adv Exp Med Biol. 2023;1415:297-301. doi: 10.1007/978-3-031-27681-1_43. PubMed PMID: 37440048; PubMed Central PMCID: PMC11342915

Pfeiffer RL, Jones BW. Current perspective on retinal remodeling: Implications for therapeutics. Front Neuroanat. 2022;16:1099348. doi: 10.3389/fnana.2022.1099348. eCollection 2022. PubMed PMID: 36620193; PubMed Central PMCID: PMC9813390

Full list of publications

Research Interests

Dr. Pfeiffer’s research interests include connectomics, 3D modeling, and transmission electron microscopy (TEM). One of her greatest accomplishments is creating three pathoconnectomes, which map out relationships between diseased tissues and retinal cells.

Research Grants

2024 Research to Prevent Blindness, Career Development Award
2024 Knights Templar Eye Foundation, Career Starter Grant